Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass
نویسندگان
چکیده
Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopulmonary arrest. During this condition, the heart-lung machine also named cardiopulmonary bypass (CPB) has to take over the circulation. It is noteworthy that the invention of a machine bypassing the heart and lungs enabled complex cardiac operations, but possible negative effects of the CPB on other organs, especially the brain, cannot be neglected. Thus, neuroprotection during CPB is still a matter of great interest. In this review, we will describe the impact of CPB on the brain and focus on pharmacological and non-pharmacological strategies to protect the brain.
منابع مشابه
Characteristics , incidence , and pathomechanisms of neurological damage during cardiac surgery
Modern-day cardiac surgery, made possible by the advent of cardiopulmonary bypass (CPB) almost six decades ago, continues to be challenged by the risk of neurologic injury. While catastrophic injury was common in the early days of CPB, advances in perfusion, anesthetic and surgical techniques now allow the vast majority of patients to undergo surgery without major morbidity or mortality. Howeve...
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